12.27.2007

Cannabinoids may modulate the spread of cancer cells

Matrix metalloproteinases (MMPs) are a family of enzymes that are involved in many physiological processes, helping to balance inflammatory signals; regulate cell growth, division, death, and cleanup; and model new tissues and blood vessels. They seem to play a central role in tumor metastasis and survival in many cases.
New research out of Germany looks at the role of anandamide and THC in reducing the invasiveness of cervical cancer cells, and seems to indicate that invasion is reduced through the cannabinoids' inhibitory effect on MMPs. The results look promising, even though they are still in vitro, and give us another insight into the immune- and inflammation-regulating power of Cannabis in the human physiology.

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